毛利 光伸MOHRI MITSUNOBU

資格

• 薬学博士
• 第1種放射線取扱主任者

著書、論文・特許

著書

• Soluble thrombomodulin. (2002) Mohri M. In: New therapeutic agents in thrombosis andthrombolysis. 2nd ed. Sasahara AA, Loscalzo J. (eds.) 323-340, Marcel Dekker Inc. New York.
• ART-123: Recombinant human soluble thrombomodulin. (2000) Mohri M. Cardiovasc Drug Rev 18:312-325

論文

• Tanaka KA, Fernandez JA, Marzec UM, Kelly AB, Mohri M, Griffin JH,Hanson SR, Gruber A;Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates.(2006) Br J Haematol 2006 132:197-203
• Phase I study of a novel recombinant human soluble thrombomodulin, ART-123. Moll S, Lindley C, Pescatore S, Morrison D, Tsuruta K, Mohri M, Serada M, Sata M, Shimizu H, Yamada K, White GC. (2004) J Thromb Haemost. 2004 2:1745-1751
• The inhibitory effect of recombinant human soluble thrombomodulin on initiation and extension in coagulation. A comparison with other anticoagulants. (1999) Mohri M, Sugimoto E, Sata M,Asano T. Thromb Haemost 82:1687-1693
• Effects of recombinant human soluble thrombomodulin (rhs-TM) on clot-induced coagulation in human plasma. (1998) Mohri M, Suzuki M, Sugimoto E, Sata M, Yamamoto S, Maruyama I. Thromb Haemost 80:925-929
• In vitro anticoagulant properties of a minimum functional fragment of human thrombomodulin and in vivo demonstration of its benefit as an anticoagulant in extracorporeal circulation using a monkey model. (1998) Suzuki M, Mohri M, Yamamoto S: Thromb Haemost 79: 417-422
• The antithrombotic effects of recombinant human soluble thrombomodulin (rhsTM) on tissue factor-induced disseminated intravasucular coagulation in crab-eating monkey (Macaca Fascicularis). (1997) Mohri M, Gonda M, Oka M, Aoki Y, Gomi K, Kiyota T, Sugihara T, Yamamoto S, Ishida T, Maruyama I. Blood Coagul Fibrinolysis 8: 274-283
• Abnormalities in the protein C anticoagulant pathway detected by a novel assay using human thrombomodulin. (1997) Mohri M, Sata M, Gomi K, Maruyama Y, Osame M, Maruyama I. Lupus 6: 590-596
• A novel assay for detecting the thrombomodulin-protein C/S anticoagulant pathway using human thrombomodulin (prothrombinase assay) (1997) Mohri M, Sata M, Gomi K, Maruyama Y, Osame M, Maruyama I. Rinsho Byori 104: 203-204 (in Japanese)
• rhs-TM prevents ET-induced increase in pulmonary vascular permeability through protein C activation. (1997) Uchiba M, Okajima K, Murakami K, Johno M, Mohri M, Okabe H, Takatsuki K. Am J Physiol 273: 889-894
• Protein C activation in NIDDM patients. (1996) Gabazza EC, Takeya H, Deguchi H, Sumida Y, Taguchi O, Murata T, Nakatani K, Yano Y, Mohri M, Sata M, Shima T, Nishioka J, Suzuki K Diabetologia 39:1455-1461
• The roles played by the D2 and D3 domains of recombinant human thrombomodulin in its function. (1995) Honda G, Masaki C, Zushi M, Tsuruta K, Sata M, Mohri M, Gomi K, Kondo S,Yamamoto S. J Biochem 118 :1030-1036
• Intravenous extended infusion of recombinant human soluble thrombomodulin prevented tissue factor-induced disseminated intravascular coagulation in rats. (1994) Mohri M, Oka M, Aoki Y, Gonda Y, Hirata S, Gomi K, Kiyota T, Sugihara T, Yamamoto S, Ishida T, Maruyama I. Am J Hematol 45:298-303
• Effects of recombinant human soluble thrombomodulin (rhs-TM) on a rat model of disseminated intravascular coagulation with decreased levels of plasma antithrombin III. (1994) Aoki Y, Ohishi R, Takei R, Matsuzaki O, Mohri M, Saitoh K, Gomi K, Sugihara T, Kiyota T, Yamamoto S, Ishida T, Maruyama I. Thromb Haemost 71:452-455
• Antithrombotic effects of recombinant human soluble thrombomodulin(rhs-M) on arteriovenous shunt thrombosis in rats. (1994) Aoki Y, Takei R, Mohri M, Gonda Y, Gomi K, Sugihara T, Kiyota T, Yamamoto S, Ishida T, Maruyama I. Am J Hematol 47:162-166
• Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxin-induced disseminated intravascular coagulation in rats. (1993) Gonda Y, Hirata S, Saitoh K, Aoki Y, Mohri M, Gomi K, Sugihara T, Kiyota T, Yamamoto S, Ishida T, Maruyama I; Thromb Res 71:325-335
• Involvement of a nuclear factor-kappa B-like protein in induction of the macrophage colonystimulating factor gene by tumor necrosis factor. (1991) Yamada H, Iwase S, Mohri M, Kufe D; Blood 78:1988-1995
• Effects of lipopolysaccharide on phospholipase A2 activity and tumor necrosis factor expression in HL-60 cells. (1990) Mohri M, Spriggs DR, Kufe D. J Immunol 144:2678-2682
• Phospholipase A2 activation and autoinduction of tumor necrosis factorgene expression by tumor necrosis factor. (1990) Spriggs DR, Sherman ML, Imamura K, Mohri M, Rodriguez C, Robbins G, Kufe DW. Cancer Res 50:7101-7107
• Regio- and stereoselective synthesis of allylic and homoallylic alcohols by the reductive desulfonylation of allylic sulfone derivatives. Application to the syntheses of (.+-.)-lavandulol and isolavandulol.(1987) Inomata K, Igarashi S. Mohri M, Yamamoto T, Kinoshita H, Kotake H.Chem Lett 4:707-710
• Palladium- catalyzed regio- and stereoselective reduction of allylic compounds with lithium triethylhydroborate. Application to the synthesis of coenzyme Q10. (1986) Mohri M, Kinoshita H, Inomata K, Kotake H, Takagaki H, Yamazaki K. Chem Lett 7:1177-1180
• Palladium-catalyzed regio- and stereoselective desulfonylation of allylic sulfones with lithium triethylhydroborate. Application to the synthesis of squalene. (1985) Mohri M, Kinoshita H,Inomata K, Kotake H. Chem Lett 4:451-454

特許

対外発表・雑誌、新聞記事等

• 日刊工業新聞にてコラム「進化した医療機器」を連載(2019年1-3月)
• 「腹腔鏡手術ロボットの市場規模と製品開発」技術情報協会(2018年5月)
• 日刊工業新聞にてコラム「医療機器新事情」を連載(2015年7-11月)

ARCリポート

• 「認知症社会に備える企業とビジネス」(No.1035、2019年5月)
• 「認知症に揺れる日本」(No.1018、2017年10月)
• 「実用的になった介護ロボット」(No.1008、2016年12月)
• 「医療用ロボット開発に有利な日本」(No.1002、2016年6月)
• 「バイオシミラー　日本はどうする」(No.993、2015年10月)

活動実績

講演

• 「遠隔医療の市場拡大動向と手術支援ロボットの可能性」情報機構(2019年1月)
• 第15回滋賀県臨床工学会 特別講演「医療・介護ロボットその実態と将来」(2017年4月)
• 「中国地域のヘルスケア産業におけるIoT・ビッグデータの活用可能性調査報告」中国経産局(広島)(2017年4月)
• 「医工連携による医療機器等における知財活用セミナー」中部経産局(名古屋)(2017年3月)
• 「医療・介護ロボットとはなにか、市場と参入戦略 -医療・介護ロボット最新事情-」情報機構(2016年10月)
• 「医療機器ビジネス参入の現状について」公益財団法人横浜市企業経営支援財団 第2回医療機器ビジネス参入促進セミナー(2016年10月)
• 「インド、アセアンにおける医療機器事業開発戦略 ~市場参入のために何が必要か~」情報機構(2016年4月)